Cancer Heterogeneity and Plasticity 2025;2(4):0018 | https://doi.org/10.47248/chp2502040018

Conference Report Open Access

Hans Clevers ¹ , Ankur Sharma ² , Sendurai A. Mani ^3,4 , Anna Golebiewska ⁵ , Axel Behrens ^6,7,8 , Wai Leong Tam ^9,10 , Loic P. Deleyrolle ¹¹ , Huiping Liu ¹² , Karuna Ganesh ^13,14 , Walid T. Khaled ^15,16 , Shaheen Sikandar ¹⁷ , Terence K. Lee ¹⁸ , Tyler E. Miller ¹⁹ , Dean G. Tang ²⁰ , Sheila Singh ^21,22,23 , Vivian S.W. Li ²⁴ , Justin D. Lathia ^25,26,27,28 , Stephanie Ma ^29,30

• 1. Pharma, Research and Early Development (pRED) of F. Hoffmann-La Roche Ltd, Basel, Switzerland
• 2. Translational Genomics Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
• 3. Department of Pathology and Laboratory Medicine, The Warren Alpert Medical School, Brown University, Providence, RI 02912, USA
• 4. Legorreta Cancer Center, The Warren Alpert Medical School, Brown University, Providence, RI 02912, USA
• 5. NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health, L-1210 Luxembourg, Luxembourg
• 6. Cancer Stem Cell Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK
• 7. Department of Surgery and Cancer, Imperial College London, London, UK
• 8. Convergence Science Centre, Imperial College London, London, UK
• 9. Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome, Singapore, 138672, Singapore
• 10. Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore, 117599, Singapore
• 11. Department of Molecular Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA
• 12. Circulating Tumor Cell Core, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA
• 13. Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
• 14. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
• 15. Department of Pharmacology, University of Cambridge, Cambridge, UK
• 16. Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK
• 17. Department of Molecular, Cell and Developmental Biology, University of California - Santa Cruz, Santa Cruz, CA, 95064, USA
• 18. Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong SAR, China
• 19. Department of Pathology, Case Western Reserve University School of Medicine and Case Comprehensive Cancer Center, Cleveland, OH, 44106-7285, USA
• 20. Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA
• 21. Department of Surgery, McMaster University, Hamilton, ON L8S 4L8, Canada
• 22. Centre for Discovery in Cancer Research, McMaster University, Hamilton, ON L8S 4L8, Canada
• 23. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada
• 24. Stem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, UK
• 25. Department of Cardiovascular & Metabolic Sciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA
• 26. Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH 44106, USA
• 27. Case Comprehensive Cancer Center, Cleveland, OH 44106, USA
• 28. Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH 44195, USA
• 29. School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
• 30. State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong SAR, China

Correspondence: Vivian S.W. Li; Justin D. Lathia; Stephanie Ma

Received: Oct 3, 2025 | Accepted: Oct 3, 2025 | Published: Oct 17, 2025