Cancer Heterogeneity and Plasticity

ISSN 2818-7792
Free Publication in 2025

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About This Journal
Cancer Heterogeneity and Plasticity (ISSN 2818-7792) is an international, peer-reviewed, Open Access (OA) journal published quarterly by Pivot Science Publications. It is dedicated to showcasing outstanding original research articles, reviews, and perspectives spanning the dynamic realm of cancer cell heterogeneity and adaptability and the complexities within their microenvironments. Its scope encompasses a wide spectrum of topics, including but not limited to the elucidation of evolutionary relationship of cancer cell subpopulations (i.e., heterogeneity), molecular mechanisms driving cancer cell plasticity (e.g., epithelial-mesenchymal transition or EMT), epigenetic underpinnings of cancer cell reprogramming (e.g., treatment-induced neuroendocrine (NE) transdifferentiation), and the influence of the tumor microenvironment (TME) on cancer cell dynamics. It extends to embrace studies exploring the impact of the microenvironment and systemic host factors (e.g., hormones, growth factors, inflammatory cytokines, and nerves) on cancer progression, therapeutic resistance, cancer cell dissemination and dormancy, metastasis, and the development of innovative targeted and combinatorial therapies.
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About Editor-in-Chief
Dean G. Tang

Distinguished Professor and Chair, Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center (RPCCC), USA

Dean Tang, PhD, is currently Distinguished Professor and Chair of Department of Pharmacology & Therapeutics at the Roswell Park Comprehensive Cancer Center in Buffalo, NY. He also holds the George Decker Endowed Chair in Developmental Therapeutics. Trained as a Pathologist, Dr. Tang obtained his PhD in Cancer Biology in 1994 from Wayne State University (Detroit, MI, USA). In 1998-2000, Dean pursued a Burroughs-Wellcome senior post-doctoral fellowship with Dr. Martin Raff at the MRC LMCB (University College London, UK) studying stem/progenitor cell development and plasticity. In June 2000, Dr. Tang joined the University of Texas M.D Anderson Cancer Center as a faculty member. After working at the M.D Anderson for 16 years, Dr. Tang was recruited to Roswell Park in June of 2016 to Chair the Department of Pharmacology & Therapeutics and Co-Lead the CCSG Developmental Therapeutic (DT) Program. He’s also the Chair of the Experimental Therapeutic (ET) Graduate Program. 
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Latest Articles
Conference Report

Advancing Cancer Biology: Highlights from the 2025 FASEB SRC on Cellular Plasticity in Cancer

Hans Clevers, Ankur Sharma, Sendurai A. Mani, Anna Golebiewska, Axel Behrens, Wai Leong Tam, Loic P. Deleyrolle, Huiping Liu, Karuna Ganesh, Walid T. Khaled, Shaheen Sikandar, Terence K. Lee, Tyler E. Miller, Dean G. Tang, Sheila Singh, Vivian S.W. Li, Justin D. Lathia, Stephanie Ma

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2502040018

Received: Oct 3, 2025 | Accepted: Oct 3, 2025 | Published: Oct 17, 2025
Review

Navigating Solid Tumor Heterogeneity: The Promise and Challenges of Antibody-Drug Conjugates

Ashley A. Duhon, Karen McLean

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2502040017

Received: Jul 21, 2025 | Accepted: Oct 3, 2025 | Published: Oct 15, 2025
Review

Regulation of Cancer Stem Cells in the Tumor Microenvironment

Aidan Li, Na Li, Yajing Yang, Linzhou Wang, Jessica Miao, Qi-En Wang

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2502040016

Received: Jul 24, 2025 | Accepted: Sep 18, 2025 | Published: Sep 26, 2025
Review

Cell Cycle Plasticity and Heterogeneity: An Underappreciated Feature of Cancer and Treatment Response

Erik S. Knudsen, Thomas N. O’Connor, Agnieszka K. Witkiewicz

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2502030015

Received: Jun 18, 2025 | Accepted: Sep 22, 2025 | Published: Sep 25, 2025
Review

Nonbone Metastasis in Prostate Cancer: Characteristics, Tumor Microenvironment, Diagnosis and Treatment

Genyu Du, Penghui Xu, Helen He Zhu, Na Jing

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2502030014

Received: Jul 11, 2025 | Accepted: Aug 22, 2025 | Published: Aug 29, 2025
Perspective

The Three Barriers Senescent Tumor Cells Must Overcome to Relapse

James G. Jackson

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2502030013

Received: May 28, 2025 | Accepted: Jul 27, 2025 | Published: Aug 4, 2025
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